Genes and accession numbers | Function | miRNAs targeting the transcript | Example of mouse strains | References |
---|---|---|---|---|
hTNF-α (NM_000594) | Regulatory role in inflammatory response and host defense against bacterial infection. | mmu-miR-466 l-3p, mmu-miR-3967, mmu-miR-8093, mmu-miR-7224-3p, mmu-miR-504-3p, mmu-miR-5127, mmu-miR-150-5p, mmu-miR-7660-3p, mmu-miR-105, mmu-miR-7049-5p, mmu-miR-721, mmu-miR-6389, mmu-miR-6341, mmu-miR-301b-3p, mmu-miR-301a-3p, mmu-miR-130c, mmu-miR-130b-3p, mmu-miR-130a-3p, mmu-miR-7086-5p, mmu-miR-6418-5p, mmu-miR-210-5p, mmu-miR-6910-5p, | hTNFalpha transgenic mice | [26] |
APOA5 (NM_052968) | Regulatory role in maintenance of plasma triglyceride levels. | mmu-miR-138-2-3p, mmu-miR-3098-3p, mmu-miR-3057-3p, mmu-miR-3085-3p, mmu-miR-3064-5p, mmu-miR-7081-3p, mmu-miR-6936-5p, mmu-miR-1894-5p, mmu-miR-7648-3p, mmu-miR-6940-5p, mmu-miR-6356, mmu-miR-361-3p, mmu-miR-762, mmu-miR-1964-5p, mmu-miR-7214-3p, mmu-miR-6979-5p | hAPOA5 transgenic mice | [16] |
hAPOAV transgenic mice | [38] | |||
APOC3 (NM_000040) | Regulatory role in maintenance of plasma triglyceride levels. Inhibition of lipoprotein lipase and hepatic lipase. | mmu-miR-7042-3p, mmu-miR-7238-3p, mmu-miR-6899-3p, mmu-miR-6950-5p, mmu-miR-7216-5p, mmu-miR-6540-3p, mmu-miR-6979-5p, mmu-miR-1982-5p, mmu-miR-7672-5p, mmu-miR-127-5p, mmu-miR-3099-5p | human apoC-III Tg mice (stock No. 006907) | [61] |
hAPOC3 transgenic mice | [16] | |||
APOA1 (NM_000039) | Involved in lipid/ cholesterol transport and metabolism. | mmu-miR-6392-5p, mmu-miR-5622-3p, mmu-miR-708-5p, mmu-miR-28a-5p, mmu-miR-5621-5p | Tg Hu ApoA1 mice (stock No. 001927) | [53] |
HD-5 (NM_021010) | Cytotoxic/ antimicrobial protein involved in host defense against pathogens. | mmu-miR-3074-5p, mmu-miR-7240-5p, mmu-miR-3473a, mmu-miR-185-5p, mmu-miR-1933-3p, mmu-miR-882, mmu-miR-145a-3p, mmu-miR-203b-3p, mmu-miR-7217-3p, mmu-miR-1264-5p, mmu-miR-7229-3p, mmu-miR-881-5p, mmu-miR-691, mmu-miR-7216-5p, mmu-miR-539-5p, mmu-miR-1897-5p, mmu-miR-12186-5p, mmu-miR-665-3p, mmu-miR-6338, mmu-miR-29b-2-5p | HD-5 transgenic mice | [40] |
HOXD3 (NM_006898) | Transcription factor that plays a regulatory role in morphogenesis. | mmu-miR-873a-5p, mmu-miR-7220-3p, mmu-miR-6370, mmu-miR-1968-5p, mmu-miR-495-3p, mmu-miR-12200-5p, mmu-miR-1192, mmu-miR-8118, mmu-miR-6394, mmu-miR-6367, mmu-miR-351-5p, mmu-miR-125b-5p, mmu-miR-125a-5p, mmu-miR-6387, mmu-miR-12186-3p, mmu-miR-1968-3p, mmu-miR-195b, mmu-miR-195a-5p, mmu-miR-7049-3p, mmu-miR-1948-5p, mmu-miR-1907, mmu-miR-6988-5p, mmu-miR-7226-5p, mmu-miR-6419, mmu-miR-6342, mmu-miR-497a-5p, mmu-miR-322-5p, mmu-miR-6353, mmu-miR-16-5p, mmu-miR-15b-5p, mmu-miR-15a-5p, mmu-miR-546, mmu-miR-497a-3p, mmu-miR-7016-5p, mmu-miR-3068-5p, mmu-miR-124b-3p | pHOXD3-transduced CD-1 mice | [8] |
p HA/HoxD3 transduced C57BL/KsJ-db/db mice | [19] | |||
3’ UTR in CETP minigene (NM_000078) | Involved in cholesteryl ester and triglyceride transfer between lipids (HDL, VLDL, LDL). | mmu-miR-6396, mmu-miR-7016-5p, mmu-miR-6967-5p, mmu-miR-1943-5p, mmu-miR-149-3p, mmu-miR-770-3p, mmu-miR-6918-3p | CETP mice (stock No. 003904) | [41] |
CDS (exon 1, 2, 13-16) in CETP minigene (NM_000078) | mmu-miR-6396, mmu-miR-487b-5p, mmu-miR-7016-5p, mmu-miR-6967-5p, mmu-miR-1943-5p, mmu-miR-149-3p, mmu-miR-3475-3p, mmu-miR-6972-5p, mmu-miR-449a-5p, mmu-miR-34a-5p | |||
IL 8/CXCL 8 (BC013615) | Chemokine involved in immune response by promoting chemotaxis and phagocytosis. | mmu-miR-140-3p, mmu-miR-6931-5p, mmu-miR-6951-5p, mmu-miR-7216-5p, mmu-miR-7675-3p, mmu-miR-497b, mmu-miR-3572-3p, mmu-miR-5101, mmu-miR-216c-5p, mmu-miR-3473f, mmu-miR-7683-3p, mmu-miR-7027-5p, mmu-miR-7116-3p, mmu-miR-682, mmu-miR-493-5p, mmu-miR-694, mmu-miR-7010-5p, mmu-miR-6951-3p, mmu-miR-376a-5p, mmu-miR-466i-3p, mmu-miR-7685-5p, mmu-miR-7670-5p, mmu-miR-212-5p, mmu-miR-466 l-3p, mmu-miR-669c-3p, mmu-miR-669d-3p, mmu-miR-467 g, mmu-miR-466e-3p, mmu-miR-466d-3p, mmu-miR-466a-3p, mmu-miR-297c-3p, mmu-miR-297b-3p, mmu-miR-297a-3p, mmu-miR-150-3p, mmu-miR-666-3p, mmu-miR-6964-5p, mmu-miR-691, mmu-miR-499-3p, mmu-miR-6998-3p, mmu-miR-7119-3p, mmu-miR-205-3p, mmu-miR-7221-3p, mmu-miR-6481, mmu-miR-6908-3p | IL-8Tg mice | [1] |
hACE2 (NM_001371415) | Enzyme that catalyzes the hydrolysis of angiotensin II into angiotensin. Also serves as receptor for coronaviruses. | mmu-miR-6964-3p, mmu-miR-465d-5p, mmu-miR-465c-5p, mmu-miR-465b-5p, mmu-miR-465a-5p, mmu-miR-7054-5p, mmu-miR-6999-5p, mmu-miR-7665-3p, mmu-miR-26b-5p, mmu-miR-26a-5p, mmu-miR-1929-5p, mmu-miR-6978-3p, mmu-miR-6338, mmu-miR-29b-2-5p, mmu-miR-6951-5p, mmu-miR-7018-5p, mmu-miR-7680-5p, mmu-miR-7221-3p, mmu-miR-802-5p, mmu-miR-6914-3p, mmu-miR-1298-3p, mmu-miR-6994-5p | K18-hACE2 mice (stock No. 034860) | [57] |
hACE2 transgenic mice (ACTB promoter) | [49] | |||
Transgenic hACE2 mice (endogenous mouse Ace2 promoter) | [2] |