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Table 1 Mus musculus miRNAs against inserted foreign genes and corresponding transgenic mice. Reporter genes like Neor, LacZ, Cre recombinase, DsRed, and TdTomato have widely been used to generate transgenic mice. However, due to their non-mammalian origin, (e.g., DsRed from Discosoma sp., GFP from Aequorea victoria, and LacZ from Escherichia coli K12), most of these genes may be potentially targeted by Mus musculus miRNAs once expressed in transgenic mice

From: Inadvertent nucleotide sequence alterations during mutagenesis: highlighting the vulnerabilities in mouse transgenic technology

Genes and accession numbers

Origin

miRNAs targeting the transcript

Example of mouse strains

References

TdTomato (LT009456)

Discosoma sp.

mmu-miR-3080-5p, mmu-miR-7019-3p, mmu-miR-1952, mmu-miR-3099-5p, mmu-miR-7659-5p, mmu-miR-1249-3p, mmu-miR-7008-5p, mmu-miR-6935-5p, mmu-miR-6922-5p, mmu-miR-7118-5p, mmu-miR-7115-5p, mmu-miR-5123, mmu-miR-6966-5p, mmu-miR-705, mmu-miR-6993-5p, mmu-miR-219b-5p, mmu-miR-6929-5p

Ai14(RCL-tdT)-D mice (stock No. 007914)

[56]

Ai9(RCL-tdT) mice (stock No. 007909)

[27]

mTmG mice (stock No. 007676)

[32]

Lac Z (b-D-galactosidase) (NC_000913)

Escherichia coli

mmu-miR-770-5p, mmu-miR-770-3p, mmu-miR-767, mmu-miR-1906, mmu-miR-203b-3p, mmu-miR-122-3p, mmu-miR-3071-3p, mmu-miR-7011-3p, mmu-miR-6372,mmu-miR-214-3p, mmu-miR-615-3p, mmu-miR-761

R26R mice (stock No. 003474)

[25]

Z/EG transgenic mice (stock No. 004178)

[37]

Z/EG transgenic mice (stock No. 003920)

[39]

Cre Recombinase (DQ023272)

Escherichia virus P1

mmu-miR-878-3p, mmu-miR-3084-3p, mmu-miR-221-5p, mmu-miR-6356, mmu-miR-7085-3p, mmu-miR-7243-5p, mmu-miR-219a-1-3p, mmu-miR-3070-5p, mmu-miR-3113-5p, mmu-miR-532-3p

Emx1IRES cre mice (stock No. 005628)

[31]

HSA-Cre79 mice (stock No. 006149)

[58]

Adipoq-Cre mice (stock No. 010803)

[44]

Agrp-Ires-cre mice (stock No. 012899)

[15]

Albumin-Cre mice (stock No. 003574)

[54]

Alb1-cre mice (stock No. 016832)

[30]

Amh-cre transgenic mice (stock No. 007915)

[60]

AQP2-Cre mice (stock No. 006881)

[59]

EGFP (U55761.1)

Escherichia coli

mmu-miR-7009-5p, mmu-miR-3098-3p, mmu-miR-509-5p, mmu-miR-7668-3p, mmu-miR-7036a-3p

Z/EG mice (stock No. 003920)

[63]

GFP (L29345)

Aequorea victoria

mmu-miR-804, mmu-miR-6979-3p, mmu-miR-5619-3p, mmu-miR-346-5p, mmu-miR-721, mmu-miR-6389,mmu-miR-6341, mmu-miR-301b-3p, mmu-miR-301a-3p, mmu-miR-130c, mmu-miR-130b-3p, mmu-miR-130a-3p, mmu-miR-344d-2-5p, mmu-miR-592-5p, mmu-miR-3094-3p, mmu-miR-9768-5p, mmu-miR-6967-3p, mmu-miR-3087-5p, mmu-miR-9-5p, mmu-miR-7093-3p, mmu-miR-7675-3p, mmu-miR-133a-5p, mmu-miR-669p-5p, mmu-miR-669 l-5p, mmu-miR-669f-5p, mmu-miR-669a-5p, mmu-miR-7683-3p, mmu-miR-7027-5p, mmu-miR-7657-5p, mmu-miR-486b-5p, mmu-miR-486a-5p, mmu-miR-6941-3p, mmu-miR-8092, mmu-miR-19b-3p, mmu-miR-19a-3p, mmu-miR-7663-3p, mmu-miR-494-5p, mmu-miR-410-5p

p25 Tg mice (stock No. 005706)

[29]

DsRed Express/MST/T1 (GQ268961)

Discosoma sp.

mmu-miR-7019-3p, mmu-miR-3080-5p, mmu-miR-1952, mmu-miR-7008-5p, mmu-miR-6935-5p, mmu-miR-6922-5p, mmu-miR-1249-3p, mmu-miR-219b-5p, mmu-miR-3099-5p, mmu-miR-7038-3p, mmu-miR-705, mmu-miR-6993-5p

DsRed.T3 transgenic mice (stock No. 005441)

[9]

Dcx-DsRed transgenic mice (stock No. 009655)

[42]

NG2DsRedBAC transgenic mice (stock No. 008241)

[18]

Neomycin Resistance Gene; Neor (NC_009980)

Salmonella enterica

mmu-miR-719, mmu-miR-323-5p

DR-4 transgenic mice (stock No. 003208)

[62]

Z/EG transgenic mice (stock No. 003920)

[63]