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Journal of Genetic Engineering and Biotechnology
Fig. 1 | Journal of Genetic Engineering and Biotechnology

Fig. 1

From: Inadvertent nucleotide sequence alterations during mutagenesis: highlighting the vulnerabilities in mouse transgenic technology

Fig. 1

Probable mechanisms of inadvertent sequence changes in transgenic mice. Genes of foreign origin such as those from humans and marker genes become potential targets of murine miRNAs once expressed within the cells of knockin/transgenic mice. Non-coding elements such as NATs and lncRNAs may get co-disrupted along with the target gene and contribute to the resulting phenotype of the mice

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