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Table 2 Online in silico analysis tools used for CDH23 protein stability changes and protein folding similarities

From: In silico analysis of a novel causative mutation in Cadherin23 gene identified in an Omani family with hearing loss

ToolPrediction value
MUproDDG = − 0.58
I-Mutant 2.0 (kcal/mol)DDG = − 1.22
DUET (kcal/mol)DDG = − 2.88
TM-score0.99786
RMSD (Å)0.44
  1. MUpro, I-Mutant 2.0, and DUET: DDG increases in protein stability > 0 > decrease in stability. 0.5 < TM-score < 1.00 reflects that the status of protein folding is identical. RMSD 0 Å − 2 Å reflects perfect match alignment