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Table 2 Online in silico analysis tools used for CDH23 protein stability changes and protein folding similarities

From: In silico analysis of a novel causative mutation in Cadherin23 gene identified in an Omani family with hearing loss

Tool

Prediction value

MUpro

DDG = − 0.58

I-Mutant 2.0 (kcal/mol)

DDG = − 1.22

DUET (kcal/mol)

DDG = − 2.88

TM-score

0.99786

RMSD (Å)

0.44

  1. MUpro, I-Mutant 2.0, and DUET: DDG increases in protein stability > 0 > decrease in stability. 0.5 < TM-score < 1.00 reflects that the status of protein folding is identical. RMSD 0 Å − 2 Å reflects perfect match alignment