Table 2 The effect of detected SNP within buffalo LEP gene on the RNA cis-acting splicing regulatory elements in LEP hrRNA
SNP | Effect | Motif | Binding factor |
|---|---|---|---|
T27C | Disrupts: intron silencer of c-src, exon n1 - Mus musculus | 26 cTctc 30 | PTB/nPTB, KSRP, FBP, hnRNP H, hnRNP F |
C32T | Creates: intron silencer of caspase-2, exon 9 - Mus musculus | 32 Tcttcc 37 | PTB |
A114G | Disrupts: exon enhancer of brca1, exon18 - Homo sapiens | 111 ctgAgtt 117 | SFRS1 (SF2/ASF) |
G263A | Disrupts: asf/sf2 - exonic splicing enhancer | 262 cGcaggt 268 | ASF/SF2 |
Creates: SRp40-exonic splicing enhancer - Homo sapiens | 263 Acagg 267 | SRp40 | |
Creates: SRp55 - exonic splicing enhancer - Homo sapiens | 261 ccAcagg 267 | SRp55 | |
A310G | Disrupts: GH exon 5 exon splicing enhancer - Bostaurus | 308 ggAag 312 | ASF/SF2 |
G379A | Disrupts: SRp55-exonic splicing enhancer - Homo sapiens | 376 tgcGgc 381 | SRp55 |
Creates: SRp40-exonic splicing enhancer - Homo sapiens | 376 tgcAgc 381 | SRp40 |