Table 2 Different strain improvement strategies employed in the production of ascomycin
From: Bioprocess and genetic engineering aspects of ascomycin production: a review
S. No | Microorganism | Techniques used | Yield (mg/L) | Reference |
|---|---|---|---|---|
1 | S. hygroscopicus var. ascomyceticus FS35 | Femtosecond laser irradiation technology | 300 | [17] |
2 | S. hygroscopicus var. ascomyceticus SA68 | Shikimic acid resistance and femtosecond laser mutation | 450 | [9] |
3 | S. hygroscopicus TD-ΔPyc-FkbO | Gene manipulation of pyc and fkbO target genes | 610 | [18] |
4 | S. hygroscopicus var. ascomyceticus | Over-expression of ccr and hcd target genes | 438.95 | [33] |
5 | S. hygroscopicus OfkbRE | Engineered LTTR FkbR1 | 536.7 | [19] |
6 | S. hygroscopicus var. ascomyceticus H16 | Chemical elicitation and combined over-expression of aroA, fkbN, and luxR/ultraviolet mutagenesis and femtosecond laser irradiation. | 1258.30 ± 33.49 | [14] |
7 | S. hygroscopicus SFK-36 | ARTP mutagenesis | 495.3 | [11] |
8 | S. hygroscopicus SFK-36 | RSM | 1476.9 | [11] |