TY - JOUR AU - Runthala, Ashish AU - Sai, Tavakala Harsha AU - Kamjula, Vandana AU - Phulara, Suresh C. AU - Rajput, Vikrant Singh AU - Sangapillai, Karthikeyan PY - 2020 DA - 2020/11/26 TI - Excavating the functionally crucial active-site residues of the DXS protein of Bacillus subtilis by exploring its closest homologues JO - Journal of Genetic Engineering and Biotechnology SP - 76 VL - 18 IS - 1 AB - To achieve a high yield of terpenoid-based therapeutics, 1-deoxy-d-xylulose-5-phosphate (DXP) pathway has been significantly exploited for the production of downstream enzymes. The DXP synthase (DXS) enzyme, the initiator of this pathway, is pivotal for the convergence of carbon flux, and is computationally studied well for the industrially utilized generally regarded as safe (GRAS) bacterium Bacillus subtilis to decode its vital regions for aiding the construction of a functionally improved mutant library. SN - 2090-5920 UR - https://doi.org/10.1186/s43141-020-00087-x DO - 10.1186/s43141-020-00087-x ID - Runthala2020 ER -