In silico design and molecular docking study of CDK2 inhibitors with potent cytotoxic activity against HCT116 colorectal cancer cell line

Journal of Genetic Engineering and Biotechnology

Table 2 Model validation parameters

Parameter	Model 1	Benchmark^a
Friedman LOF	0.2006
R-squared (R²)	0.7397	≥ 0.6
Adjusted R-squared (R²_adj.)	0.6712	≥ 0.6
Cross validated R-squared (Q²_cv)	0.5547	≥ 0.5
Significant regression?	Yes	Yes
External validation (R²_ext.)	0.7202	≥ 0.6