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Table 1 Experimental design

From: Therapeutic potential of a novel combination of Curcumin with Sulfamethoxazole against carbon tetrachloride-induced acute liver injury in Swiss albino mice

Groups

Dose

Method of section

Duration

Group I negative control

0.5 ml olive oil/kg b.w.

i.p

3 times a week for 5 weeks

Group II DMSO control

(0.2%) DMSO

i.p

3 times a week for 4 weeks

Group III CCl4 control

1 ml (50% in olive oil)/kg b.w.

i.p

3 times a week for 5 weeks

Group IV CUR group

CCl4 as group III followed by CUR 100 mg/kg b.w. in olive oil [45, 46]

CCl4 i.p

CUR orally through a gastric tube

CCl4 3 times a week for 5 weeks then

4 times a week for 4 weeks

Group V CUR control

100 mg/kg b.w. in olive oil [45, 46]

orally through a gastric tube

4 times a week for 4 weeks

Group VI SMX Group

CCl4 as group III followed by 15 mg SMX/kg b.w. in DMSO [47]

i.p

CCl4 3 times a week for 5 weeks then

4 times a week for 4 weeks

Group VII SMX control

15 mg SMX/kg b.w. in DMS O[47]

i.p

4 times a week for 4 weeks

Group VIII Combination (CUR + SMX) group

CCl4 as group III followed by CUR as group V and SMX as group VII

CCl4 and SMX i.p

CUR orally through a gastric tube.

CCl4 3 times a week for 5 weeks then

4 times a week for 4 weeks

Group IX Combination (CUR. + SMX.) control

CUR as group V and SMX as group VII

CUR orally through a gastric tube. SMX i.p

4 times a week for 4 weeks

  1. CCl4 carbon tetrachloride, CUR curcumin, SMX sulfamethoxazole, i.p intraperitoneally